Beryl J. Ortwerth

Professor Emeritus of Biochemistry

Email:	ortwerthb@missouri.edu
Phone:	(573) 882-6092
Office:	C-112 Eye Institute East
Mailing Address:	Eye Institute - East 404 Portland Street Columbia, MO 65201
Research Areas:	Lens protein modification by ascorbic acid glycation; the role of UVA light in human cataract formation.

Educational Background

Notable Honors and Service

Selected Publications

Argirov, O.K., Lin, B. and Ortwerth, B.J., 2-Ammonio-6-(3-oxidopyridinium-1-yl)hexanoate (OP-lysine) is a newly identified advanced glycation endproduct in cataractous and aged human lenses. J. Biol. Chem. 279:6487-6495 (2004).

Cheng, R., Feng, Q., Argirov, O.K. and Ortwerth, B.J., Structure elucidation of a novel yellow chromophore from human lens protein. J. Biol Chem. 279:45441-45449 (2004).

Cheng, R., Feng, Qi and Ortwerth, B.J., LC-MS display of the total modified amino acids in cataract lens proteins and in lens proteins glycated by ascorbic acid in vitro. Biochim. Biophys. Acta 1762:533-543 (2006).

Fan, X., Reneker, L.W., Obrenovich, M.E., Strauch, C., Cheng, R., Jarvis, S.M., Ortwerth, B.J., and Monnier, V.M., Vitamin C mediates chemical aging of lens crystallins by the Maillard reaction in a humanized mouse model. Proc. Natl. Acad. Sci. U.S.A. 103:16912-16917 (2006).