Kent Gates

Professor of Chemistry

Email:	gatesk@missouri.edu
Phone:	(573) 882-6763
Fax:	(573) 882-2754
Office:	325 Chemistry Building
Mailing Address:	Chemistry 125 Chemistry Building University of Missouri-Columbia Columbia, MO 65211
Research Areas:	Mechanisms of DNA damage by synthetic and naturally occurring antitumor agents, toxins, and mutagens.
Webpage:	http://www.chem.missouri.edu/GatesGroup/Research.html

Educational Background

Research Description

Selected Publications

DNA strand damage analysis provides evidence that the tumor cell-specific cytotoxin tirapazamine produces hydroxyl radical and acts as a surrogate for molecular oxygen Chowdhury, C.; Junnotula, V.; Daniels, J. S.; Greenberg, M. M.; Gates, K. S. J. Am. Chem. Soc. 2007, 129, 12870-12877.

Kinetics and mechanism of protein tyrosine phosphatase 1B inactivation by acrolein. Seiner, D. R.; LaButti, J. N.; Gates, K. S. Chem. Res. Toxicol. 2007, 20, 1315-1320.

Chemical reactions of DNA damage and degradation (click here to access an order form for this book) Gates, K. S. Reviews of Reactive Intermediate Chemistry, Platz, M.; Moss, R. A.; Jones, M. Jr., Eds. John Wiley & Sons, New York. 2007, pp. 333-378.

Synthesis and biological evaluation of new 2-arylcarbonyl-3-trifluoromethylquinoxaline 1,4-di-N-oxide derivatives and their reduced analogues Solano, B.; Junnotula, V.; Marin, A.; Villar, R.; Burguete, A.; Vicente, E. ; Perez-Silanes, S.; Monge, A.; Dutta, S.; Sarkar, U.; Gates, K. S. J. Med. Chem. 2007, X, 5485-5492.

Entering the leinamycin rearrangement via 2-(trimethylsilyl)ethyl sulfoxides Keerthi, K.; Gates, K. S. Org. Biomol. Chem. 2007, 5, 1595-1600.

Redox Regulation of Protein Tyrosine Phosphatase 1B (PTP1B) by Peroxymonophosphate (=O3POOH) LaButti, J.; Chowdhury, G.; Reilly, T. J.; Gates, K. S. J. Am. Chem. Soc. 2007, 129(17), 5321-5322.

Interstrand Cross-links Generated by Abasic Sites in Duplex DNA Dutta, S.; Chowdhury, G.; Gates, K. S. J. Am. Chem. Soc. 2007, 129(7), 1852-1853.

Stabilities and Spin Distributions of Benzannulated Benzyl Radicals Sui, Y.; Glaser, R.; Sarkar, U.; Gates, K. S. J. Chem. Theory and Comput. 2007, 3(3), 1091-1099.