Susan L. Deutscher

Professor of Biochemistry

Email:	deutschers@missouri.edu
Phone:	(573) 882-2454
Lab:	(573) 882-1493
Fax:	(573) 882-5635
Office:	234C Schweitzer Hall
Mailing Address:	Biochemistry 117 Schweitzer Hall University of Missouri-Columbia Columbia, MO 65211
Research Areas:	Combinatorial biology applied to cancer detection and therapy.

Educational Background

BS		Purdue University	West Lafayette, Ind.	Cell Biology
PhD		St. Louis University	St. Louis, Mo.	Biochemistry

Notable Honors and Service

Co-Director, NIH/NEI Center for Single Photon-Emitting Cancer-Imaging Agents
Veterans Administration Research Merit Award (1994-1996; 1998-2010)

Research Description

Our laboratory is interested in discerning the role of carbohydrate and protein-protein interactions in cancer. Work focuses on applying novel combinatorial phage display approaches and structural biochemistry to characterize these interactions. Combinatorial chemistry and phage display allows for the rapid selection from many millions of sequences to find peptide molecules that bind almost any given target such as cancer antigens. We have isolated peptides that are being utilized to specifically modulate cancer cell adhesion events. Once radiolabeled, the peptides will prove valuable as selective cancer imaging and therapeutic agents.

Selected Publications

Glinsky VV. Glinsky GV. Glinskii OV. Huxley VH. Turk JR. Mossine VV. Deutscher SL. Pienta KJ. Quinn TP. (2003) Intravascular metastatic cancer cell homotypic aggregation at the sites of primary attachment to the endothelium. Cancer Research. 63(13):3805-11, 2003.

Landon, L., Zou, J., and Deutscher, S.L. (2004) Is Phage Display Technology on Target for Developing Peptide-based Drugs? Current Drug Discovery Technologies, 1, 113-132.

Zou, J., Dickerson, M., Owen, N.K., Landon, L.A., and Deutscher, S.L. (2004) Biodistribution and Immune Response of Filamentous Phage Peptide Libraries in Mice. Molecular Biology Reports, 31, 121-129.

Zou, J., Glinsky, V.V., Landon, L., Matthews, L., and Deutscher, S.L. (2005) Peptides Specific to the Galectin-3 Carbohydrate Recognition Domain Inhibit Metastasis-Associated Cancer Cell Adhesion. Carcinogenesis. 26(2):309-318.

Kumar, SR, Sauter, ER, Quinn, TP and Deutscher, SL. (2005) Thomsen-Friedenreich and Tn Antigens in Nipple Fluid: Carbohydrate Biomarkers for Breast Cancer Detection. Clinical Cancer Research 2005 11: 6868-6871.

Newton JR, Kelly KA, Mahmood U, Weissleder R and Deutscher SL. (2006) In vivo selection of phage for the optical imaging of human prostate carcinoma in mice. Neoplasia 8, 772-780

Newton, JR, Miao, Y, Deutscher, SL and Quinn, TP. (2007) Melanoma Imaging with Pretargeted Bivalent Bacteriophage. Journal of Nuclear Medicine 48, 429-436.

Employment Opportunities

Post-Doctoral Opportunities

Electronic submission is encouraged, e-mail to biochemsearch@missouri.edu

Applicants should send CV and names of two references to:
Dr. Susan Deutscher
Postdoctoral Application
Biochemistry
117 Schweitzer Hall
University of Missouri-Columbia
Columbia, MO 65211

Combinatorial biology applied to cancer detection and therapy.